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Valentis, Inc.
Bennet Weintraub
CFO, VP Finance
(650) 697-1900 x.214
bweintraub@valentis.com
SCO Financial Group LLC
Douglas Tsao
1-212-554-4158
dtsao@scogroup.com
Burns McClellan, Inc.
Stephanie Diaz
(investors)
(415) 352-6262
sdiaz@sf.burnsmc.com
FOR IMMEDIATE RELEASE

Valentis Licenses GeneSwitch® Technology to Pfizer for Research

October 24, 2001 Burlingame, CA — Valentis, Inc. (NASDAQ:VLTS) Valentis (Nasdaq: VLTS) today announced that it has granted a non-exclusive license to Pfizer, Inc (NYSE: PFE) for the Company's GeneSwitch(TM) gene regulation technology. This is the fourth such license Valentis has granted to major pharmaceutical and biotechnology companies since February 2001. The non-exclusive license is for research purposes only. Financial terms were not disclosed. Valentis maintains all rights to clinical gene therapy applications of the GeneSwitch(TM) gene regulation technology.

The GeneSwitch(TM) gene regulation system allows researchers to control the level and duration of selected genes in transgenic animals and cell cultures, aiding in the identification and characterization of a gene's function. Valentis also is currently developing the GeneSwitch(TM) gene regulation system as a component for its own Genemedicine(TM) products delivered with the Company's synthetic (lipid and polymer) delivery systems. Further technical and licensing information on the GeneSwitch(TM) gene regulation technology can be found at http://www.geneswitch.com.

Valentis converts genomic discoveries into medicines. The Company applies its proprietary synthetic, lipid and polymer, gene delivery, gene regulation, and PEGylation technologies to create novel therapeutic products in the fields of cardiovascular disease, oncology, hematology, and infectious diseases. Enabled by its expertise in preclinical research & development, clinical development, and manufacturing, Valentis has created a broad product portfolio designed to improve the safety, efficacy and dosing characteristics of genes, proteins, peptides, antibodies, viruses and liposomes. Additional information about Valentis can be found at http://www.valentis.com.

Statements in this press release that are not strictly historical are "forward-looking" statements as defined in the Private Securities Litigation Reform Act of 1995. The words "believes," "expects," "intends," "anticipates," variations of such words, and similar expressions identify forward-looking statements, but their absence does not mean that the statement is not forward-looking. These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could affect Valentis' actual results include the need for additional capital, the early stage of product development, uncertainties related to clinical trials, and uncertainties related to patent position. There can be no assurance that Valentis will be able to develop commercially viable Genemedicine(TM) products or PEGylated biopharmaceuticals, that any of the company's programs will be partnered with pharmaceutical partners, that necessary regulatory approvals will be obtained, or that any clinical trial will be successful. Actual results may differ from those projected in forward-looking statements due to risks and uncertainties that exist in the companies' operations and business environments. These are described more fully in the Valentis Annual Report on Form 10-K for the period ended June 30, 2001 filed with the Securities and Exchange Commission.